Fig. 2: Genomic landscape and characteristics of prospectively sequenced Chinese breast cancer. | Nature Communications

Fig. 2: Genomic landscape and characteristics of prospectively sequenced Chinese breast cancer.

From: Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing

Fig. 2

a Sequencing data of 1134 Chinese breast cancer samples classified by the molecular subtype and mutation profile and annotated with the variation type and mutation frequency. The mutation counts in each sample and each gene are provided above and on the right side, respectively. b Hotspot mutations (frequency higher than 2%) in Chinese breast cancer. c Copy number variations (CNVs) of 1114 Chinese breast cancer samples classified by the molecular subtype in our cohort. d Distribution of variant allele fractions (VAFs) in the recurrently mutated genes. e Recurrent genomic mutations (left and right) and their association with different molecular subtypes (middle). The asterisks indicate a statistically significant association with the subtype (FDR < 0.25).

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