Fig. 3: Comparison of N. meningitidis essential genome to that of other bacteria.

a Edwards–Venn diagram displaying overlaps between essential genes in bacteria in which complete libraries of mutants have been constructed: N. meningitidis (black line), E. coli (green line)10, A. baylyi (red line)12 and S. sanguinis (blue line)13. To perform this analysis, we queried the DEG database65 of essential genes using our set of essential genes. The corresponding datasets are listed in Supplementary Data 6. b Comparison of N. meningitidis essential genome (black line) to JCVI-syn3.0 (red line), a synthetic M. mycoides designed with a minimal genome22. The corresponding datasets are listed in Supplementary Data 7.