Fig. 4: Concise cellular overview of the essential meningococcal genome. | Nature Communications

Fig. 4: Concise cellular overview of the essential meningococcal genome.

From: Construction of a complete set of Neisseria meningitidis mutants and its use for the phenotypic profiling of this human pathogen

Fig. 4

Essential genes were integrated into networks and metabolic pathways using primarily MetaCyc25. The four basic functional groups are highlighted using the same colour code as in Supplementary Fig. 2, i.e. orange (gene/protein expression), green (genome/cell replication), blue (cell membrane/wall biogenesis) and yellow (cytosolic metabolism). The 34 essential genes that could not be clearly assigned to one of these four categories are not represented on the figure. Genes involved in the different reactions are indicated by their name or NMV_ label, in red when essential, in black when dispensable. *Genes involved in more than one pathway. Key compounds/proteins are abbreviated as follows. ACP acyl carrier protein, AIR aminoimidazole ribotide, CDP-DAG CDP-diacylglycerol, CMP-Kdo CMP-ketodeoxyoctonate, DHAP dihydroxyacetone phosphate, DPP dimethylallyl diphosphate, DXP 1-deoxyxylulose-5P, Fe-S iron-sulfur, FMN flavin mononucleotide, G3P glyceraldehyde-3P, Glu-6P glucose-6P, IMP inosine monophosphate, IPP isopentenyl diphosphate, LOS lipo-oligosaccharide, M-DAP meso-diaminopimelate, NaMN nicotinate d-ribonucleotide, OPP all-trans-octaprenyl diphosphate, PE phosphatidylethanolamine, PG phosphatidylglycerol, PHBA p-hydroxybenzoate, PRPP 5-phosphoribosyl diphosphate, Rib-5P ribulose-5P, SAM S-adenosyl-methionine, UDP-GlcNAc UDP-N-acetyl-glucosamine, UPP di-trans-poly-cis-undecaprenyl diphosphate. The corresponding datasets are listed in Supplementary Data 8.

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