Table 1 Essential meningococcal genes listed by functional category/sub-category.
Functional category/sub-category | Number of genes | % of total |
|---|---|---|
Gene/protein expression | 150 | 38.4 |
Ribosomal protein | 51 | 13 |
Aminoacyl-tRNA synthesis | 24 | 6.1 |
Protein export | 21 | 5.4 |
RNA modification/degradation | 19 | 4.9 |
DNA transcription | 11 | 2.8 |
Translation factors | 10 | 2.6 |
Protein folding | 7 | 1.8 |
Ribosome biogenesis/maturation | 5 | 1.3 |
Protein post-translational modification | 2 | 0.5 |
Genome/cell replication | 33 | 8.4 |
Chromosome replication/maintenance | 20 | 5.1 |
Cell division | 13 | 3.3 |
Cell membrane/wall biogenesis | 54 | 13.8 |
Peptidoglycan biosynthesis/recycling | 17 | 4.3 |
LOS biosynthesis | 14 | 3.6 |
Fatty acid biosynthesis | 12 | 3.1 |
Phospholipids biosynthesis | 8 | 2 |
UDP-GlcNAc biosynthesis | 3 | 0.8 |
Cytosolic metabolism | 120 | 30.7 |
Vitamins biosynthesis | 24 | 6.1 |
Nucleotide biosynthesis | 15 | 3.8 |
Aerobic respiration/cytochrome c | 12 | 3.1 |
Amino acid metabolism | 9 | 2.3 |
Isoprenoid biosynthesis | 9 | 2.3 |
Electron transport | 9 | 2.3 |
Heme biosynthesis | 9 | 2.3 |
Sugar metabolism | 9 | 2.3 |
Fe-S cluster biosynthesis | 6 | 1.5 |
CoA/ac-CoA biosynthesis | 6 | 1.5 |
Ubiquinol biosynthesis | 4 | 1 |
NAD/NADP biosynthesis | 3 | 0.8 |
Lipoate biosynthesis | 2 | 0.5 |
SAM biosynthesis | 1 | 0.3 |
Phosphate metabolism | 1 | 0.3 |
Sulfur metabolism | 1 | 0.3 |
Unassigned | 34 | 8.7 |
Total | 391 | 100 |
