Fig. 3: Analyses of the genetic overlap between brain volume and intelligence.
From: Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence
a Q-Q plot showing the observed and expected P-value distribution of 24 lead variants of the brain volume (BV) meta-analysis in intelligence (INT) and b 243 intelligence meta-analysis lead variants in BV. The colors denote the concordance (/discordance) of effects between the two traits. c Mendelian Randomization analysis, showing the effect size and standard errors of each variant of BV (bzy) on intelligence (bzx) and the diagonal line showing the estimated causal effect (bxy) of BV on intelligence. d Similar to (c) but of intelligence on BV. e Venn diagrams showing the number of overlapping loci, significant variants, and genes implicated in BV and intelligence by FUMA and MAGMA. f Karyogram showing the genomic position of the 92 genes that were implicated in the GWAS of both BV and intelligence. g Comparison of the pLI score (representing tolerance to loss-of-function variants) and fraction of genes involved in developmental disorders (DECIPHER database) between BV-only genes, intelligence-only genes (INT), genes associated to both traits (BV + INT), and all genes. h Cortical gene expression patterns (darker colors indicate higher rank scores) across 57 cortical areas of the 92 genes that overlap between BV and intelligence (top panel), and the two clusters of genes (middle and bottom panel).
