Fig. 6: Tumour clonality.

a Heatmap showing the average VAF value of mutations of each gene (columns) in the samples where at least one mutation was detected (rows). The genes are ordered according to hierarchical clustering, and samples are ordered according to diagnosis (see colour code). b For each diagnosis, the distribution of the VAF of somatic mutations in one sample is shown. Grey bars represent the number of mutations for each gene. c Representative plots of VAF distribution of somatic mutations for higher-grade samples annotated with driver mutations. Mutations with relatively high frequency (f > 0.25) are likely to be clonal (public).