Fig. 3: Hotspot missense mutations in the SMARCA4 ATPase helicase domain. | Nature Communications

Fig. 3: Hotspot missense mutations in the SMARCA4 ATPase helicase domain.

From: Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients

Fig. 3

a Lollipop plots of SMARCA4 missense mutations in TCGA (top, n = 379 missense variants) and the FoundationCORE® (bottom, n = 6289 missense variants) cohorts. b Locations of frequently mutated residues on a SMARCA4 homology model derived from yeast Snf2-nucleosome complexes (PDB: 5X0X48 and PDB:5Z3U49). c Amino acid changes of frequently mutated SMARCA4 residues.

Back to article page