Fig. 6: N-cadherin is involved in scar formation in human skin. | Nature Communications

Fig. 6: N-cadherin is involved in scar formation in human skin.

From: Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin

Fig. 6

a, b whole-mount bright-field image and Masson’s trichrome staining of SCADs made from human eyelid skin (a) or thigh skin (b) 14 days after culture (middle). The histology of respective fresh SCADs is shown in right column. n > 100. c Immunolabelling of N-cadherin (red) and FSP1 (green) of human SCAD at day 0 and day 14. d–g Masson’s trichrome staining and 3D immunostaining of N-cadherin on biopsy from human breast hypertrophic scar (d, e) or adjacent breast skin (f, g). N-cadherin (magenta), SHG (cyan). The enlarged images of the N-cadherin channel indicated by white boxes in e, g are shown in e′, e″, e″′ and g′, respectively. Scale bars = 500 µm, except e′–e″′, g′ = 20 µm.

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