Fig. 7: Enhancer co-amplification determines MYCN amplicon patterns.
From: Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
In most cases, MYCN and its local gene-regulatory neighborhood including a CRC-driven super-enhancer is amplified (Class I). If the local neighborhood is not co-amplified, amplicons are more complex and recruit distal gene-regulatory elements (Class II).
