Fig. 5: MOL2 and MOL5/6 show differential susceptibility to disease.

a, b, l–m Schematic of the different models of traumatic spinal cord injury as well as the lesions relative extent and distribution (a, l), level of the lesions (T9-10. b, m) and distance of the rostral and caudal analyzed segments (b, m). c, f, g, n, o Confocal representative images of the lesions following dorsal funiculi transection (c, f, g) and contusion (n, o) injuries, showing the specific loss of MOL2 (Klk6⁺ OL lineage cells) and the high repopulation by MOL5/6 (Ptgds⁺ OL lineage cells) of the lesions during the chronic phase following traumatic spinal cord injury (f, g, n, o), but not at the acute phase (c). Yellow dashed lines highlight the lesion sites. White rectangles highlight the regions shown in higher magnification. Scale bar = 100 μm. d, e, h, i, j, k, p, q Quantification of the OL lineage (d, h, i, p) and the MOL populations away and at the injury sites (e, j, k, q). Percentage of the MOL2 and MOL5/6 subpopulations was calculated on the total number of OL lineage cells (Sox10⁺ cells). Dashed black line marks the average percentage of the OL lineage cells in the intact adult spinal cord (d, h, p). Data are presented as mean ± SEM. n = 3–7 animals per condition, and can be assessed in the Source Data file. Asterisks indicate a significant difference between conditions (*p ≤ 0.05, **p ≤ 0.01, two-way ANOVA with Sidak’s correction). Exact p values are reported in the Source Data file. SCI spinal cord injury, dpi days post-injury, mpi months post-injury, T10 thoracic vertebra 10. MOL mature oligodendrocyte. Source data are provided as a Source Data file.