Fig. 5: Organization of ion pathway constriction sites (CSs) in OLPVR1.

a Three CSs and cavities are forming the putative ion-conductive pathway in viral CCRs and highly conservative residues of OLPVR1. TM6 and TM7 helices are omitted for clarity. Membrane core boundaries were calculated using PPM server¹⁰³ and are shown with gray lines. b Magnified view of the CSs in OLPVR1 (left, present work), CrChR2 (middle, PDB ID: 6EID⁸) and (right, PDB ID: 6CSM¹⁰) structures, colored cyan, yellow and green, respectively. Water accessible cavities were calculated using HOLLOW¹⁰⁵ and are presented as a pink surface.