Fig. 2: Lkb1 deletion in the hepatocytes affects body composition and whole-body metabolism.

a–c Changes in whole-body composition analyzed after tamoxifen injection in Lkb1KO^livad (KO) mice. a Body weight (g) and of the percentage of total body weight accounted for by lean body mass (b) (g/bw) and fat mass (c) (g/bw), for KO (n = 6) and control (WT, n = 6) mice over a period of 9 weeks. Data are expressed as means ± SEM. P values were determined by unpaired two-tailed t-test. *p ≤ 0.05. Tamoxifen was injected into the animals on day 0 (black arrow); calorimetric analysis was performed from day 14 to day 18. d Mean daylight-, night- and 24 h mean food intake (g/kg lean body mass/h). e Mean daylight-, night- and 24 h- mean spontaneous locomotor activity (beam break). f Mean daylight-, night- and 24 h mean energy expenditure (kcal/kg lean body weight/h). g Mean daylight-, night- and 24 h mean energy balance. h Mean daylight-, night- and 24 h mean respiratory exchange ratio (VCO₂/VO₂) of KO and control mice. Means over 24 h were calculated from 96 h measurements. All graphical data (d–h) are expressed as the mean ± SEM of 6 animals per group. P values were determined by unpaired two-tailed t-test. *p ≤ 0.05; **p ≤ 0.01. Source data are provided as a Source data file.