Fig. 1: Platelets recruited to inflamed blood vessels are migratory and form lamellipodia.
From: Vascular surveillance by haptotactic blood platelets in inflammation and infection
a, b Platelet recruitment and migration in inflamed microvessels. a Representative micrograph and b platelet migratory behavior, exemplary observed patterns, tracks (white) and cell velocities (n = 39 cells in five mice). White arrows: platelets. c, f Platelet phenotype and microenvironment in LPS-induced inflammation and ferric chloride-induced thrombosis in the cremaster microvasculature. c Fibrin(ogen) deposition and d associated platelet phenotype in inflammatory settings. Asterisks: lamellipodia. e Platelet phenotype and f fibrin(ogen) deposition in thrombosis. White arrows: filopodia. c, f Right lower insets: rendered 3D reconstructions. g Directionality of in vivo migrating (n = 39, see b compared to retracting cells (mesenteric thrombus formation, n = 59 cells in three mice), Mann–Whitney. h Analysis of in vivo platelet shape in the cremaster microvasculature, n = 26 (thrombosis), n = 33 (inflammation) in three mice, Mann–Whitney. Scale bars =5 µm. All statistical tests are two-sided. Source data are provided as a Source Data file.
