Fig. 4: Family of symptomatic SARS-CoV-2 PCR positive parents and SARS-CoV-2 PCR negative children have distinct serological responses compared to healthy individuals, characterized by elevated SARS-CoV-2 specific responses.
From: Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19
a PLSDA scores plot of healthy (blue triangles) vs family (circles) containing both SARS-CoV-2 PCR positive parents (orange) and negative children (yellow) exhibited 98.0% calibration and 96.0% cross-validation accuracy, with 62.7% of variance explained by LV1 (x-axis). Family member samples are labeled with A (adult) or C (child) with the day of sample collection listed after D. b PLSDA plot of LV1 loadings driving the separation of groups, where negatively loaded features are associated with the family members. c Hierarchical clustering of healthy individuals (blue) and family members (parents, orange; children, yellow) using a feature-selected serological signature, where red indicates a relatively high antibody response and blue a relatively low antibody response (z-score). Samples (x-axis) are labeled with H (healthy non-household members), and A (adult) or C (child). Day of sample collection is listed at the end of family member sample labels.
