Fig. 6: Global transcriptome alteration in primary fibroblasts of AGO2 patients.
From: Germline AGO2 mutations impair RNA interference and human neurological development
a, b Venn diagram of upregulated (a) and downregulated (b) transcripts in fibroblasts isolated from AGO2 patients (cases 2, 3, and 14) compared to five age-matched controls. The number of the upregulated (a) or downregulated (b) genes in all three cases are marked red, whereas deregulated genes in both cases bearing the p.L192P mutation are marked yellow.
