Fig. 4: OCTFs dynamically target stress response genes during the genotoxic response. | Nature Communications

Fig. 4: OCTFs dynamically target stress response genes during the genotoxic response.

From: Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response

Fig. 4

a Motif discovery analysis of differential quantitative COGC-seq peaks using Homer. The binomial test P value of each motif is shown. b The chromatin binding sites and target genes of 367 putative TFs generated by the motif discovery analysis of COGC-seq peaks are shown in heat maps (red, high; blue, low). c Overlap of 367 enriched TFs identified from the motif discovery analysis with 88 differential quantitative OCTFs in MS/MS is shown in a Venn diagram. The quantification of the 33 overlapping O-GlcNAc TFs is shown in a heat map (red, high; blue, low). d Venn diagram showing the overlapped peak-associated genes identified from MCF-7 and ADR-biased COGC-seq regions. e GO analysis of MCF-7 and ADR-biased peak-associated genes. The gene numbers identified in certain terms are shown. Source Data are provided as a Source Data file. f Integrative Genomics Viewer (IGV) tracks showing COGC-seq signal at the promoter regions of the representative genes PPP2R5B, DNAJA1, PDCL3, and MAN2C1.

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