Fig. 1: PTSD associates with DNA methylation differences across the genome. | Nature Communications

Fig. 1: PTSD associates with DNA methylation differences across the genome.

From: Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR

Fig. 1

a Manhattan plot for the meta-analysis of 10 cohorts (Ncases = 878, Ncontrols = 1,018). Association analyses of each cohort are based on empirical Bayes method. Meta-analysis is done by sample size-weighted sum of z-scores. p-values are two-sided and unadjusted for multiple testing. All of the association models are adjusted for sex (if applicable), age, CD8, CD4, NK, B cell, and monocyte cell proportions, and ancestry using principal components (PCs). The x-axis is the location of each site across the genome. The y-axis is the –log10 of the p-value for the association with PTSD. The dashed line indicates statistical significance at p < 3.6E-8.

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