Fig. 1: Overview of manifold learning for unraveling staging in Alzheimer’s disease.
From: Molecular estimation of neurodegeneration pseudotime in older brains
a Illustration of steps in manifold learning using reverse graph embedding DDRTree method. b Illustration of lineage inference process for LOAD. RNA-seq samples with different disease diagnoses were pooled, batch normalized, and a smooth manifold was learned for each brain region across individuals (each point is an individual). Total sample numbers are indicated across Mayo RNA-seq TCX and ROS/MAP DLPFC for the different diagnoses in parentheses.
