Fig. 2: Manifold learning accurately infers disease states and stages from RNA-seq samples. | Nature Communications

Fig. 2: Manifold learning accurately infers disease states and stages from RNA-seq samples.

From: Molecular estimation of neurodegeneration pseudotime in older brains

Fig. 2

a Estimated disease progression trees from temporal cortex (TCX) and b dorsolateral prefrontal cortex (DLPFC) brain regions showing localization of identified LOAD samples on particular branches. c Distribution of pseudotime for AD cases and controls for both DLPFC and TCX for 218 independent samples from two independent studies. d Distribution of expression correlation with pseudotime for both LOAD GWAS genes and non-LOAD GWAS genes for 17446 genes from two independent studies. Box plots have lower and upper hinges at the 25th and 75th percentiles and whiskers extending to at most 1.5xIQR (interquartile range).

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