Table 1 Pathway enrichments for branch-specific differentially expressed genes in TCX.
From: Molecular estimation of neurodegeneration pseudotime in older brains
Direction | Branch | Representative enriched Gene Ontology terms |
|---|---|---|
Down | 2 | prespliceosome (GO:0071010), mitochondrial electron transport cytochrome c to oxygen (GO: 0006123) |
Down | 3 | negative regulation of microtubule, polymerization or depolymerization (GO:0031111) |
Down | 4 | mitochondrial electron transport, NADH to ubiquinone (GO: 0006120), spliceosomal tri-snRNP complex (GO:0097526), negative regulation of microtubule depolymerization (GO:0007026) |
Down | 5 | axon (GO:0030424), protein kinase C activity (GO:0004697) |
Down | 6 | gamma-tubulin large complex (GO:0000931), U1 snRNP (GO:0005685), mitochondrial respiratory chain complex IV (GO:0005751), response to cadmium ion (GO:0046686) |
Up | 3 | fatty acid elongase activity (GO:0009922), ubiquitin protein ligase activity (GO:0061630) |
Up | 4 | transforming growth factor beta-activated receptor activity (GO:0005024), hippo signaling (GO:0035329), regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO: 1902041), regulation of DNA repair (GO: 0006282) |
Up | 5 | regulation of apoptotic process (GO:0042981), leptin mediated signaling pathway (GO:0033210), negative regulation of hippo signaling (GO:0035331), small GTPase binding (GO:0031267) |
Up | 6 | extracellular ligand-gated ion channel activity (GO:0005230), integral component of mitochondrial inner membrane (GO:0031305) |
