Table 2 Pathway enrichments for branch-specific differentially expressed genes in DLPFC.

From: Molecular estimation of neurodegeneration pseudotime in older brains

Direction

Branch

Representative enriched Gene Ontology terms

Down

2

DNA repair (GO:0006281), intracellular protein transport (GO:0006886)

Down

3

mismatch repair complex binding (GO:0032404)

Down

5

mitochondrial respiratory chain complex assembly (GO: 0033108)

Up

2

racemase and epimerase activity (GO: 0016857)

Up

3

racemase and epimerase activity (GO: 0016857)

Up

4

vesicle mediated transport (GO: 0016192)

Up

5

NuRD complex (GO: 0016581)

Up

6

microtubule motor activity (GO:0003777), AP-2 adapter complex binding (GO:0035612)

  1. Differential expressed genes are identified with a two-sided Tukey’s honest significant difference test (FDR < 0.05), with Branch 1 as the reference, and pathway enrichments that are significant from a one-sided Fisher’s exact test are shown (FDR < 0.05).