Fig. 1: IRF3 in intestinal epithelium protects against colonic tumorigenesis.
From: IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
a Representative images of colon tumors from IRF3+/+ and IRF3−/− mice on day 90 after AOM/DSS model. b–d Colon tumor counts, size, and tumor load from IRF3+/+ and IRF3−/− mice (n = 15 mice/group) after AOM/DSS model (day 90). e Representative images of the small intestine and tumors in Apcmin/+ and Apcmin/+IRF3−/− mice. f–h Intestinal tumors counts, size, and tumor load from Apcmin/+ and Apcmin/+IRF3−/− mice (n = 15 mice/group). i–l Three groups of mice were generated by bone marrow transplantation: IRF3+/+ → IRF3+/+, n = 10; IRF3−/− → IRF3+/+, n = 10; IRF3+/+ → IRF3−/−, n = 8; the numbers and size of tumors in the colon were quantified after AOM/DSS model (day 90). m–p Colon tumor counts, size, and tumor load from IRF3fl/fl and IRF3fl/fl Villincre mice (n = 13 mice/group) representative images of colons at left (m) after AOM/DSS model (day 90). Each symbol represents one mouse (b–d, f–h, j–l, n–p). *P < 0.05; **P < 0.01; ***P < 0.001; NS not statistically significant by two-tailed t test (b–d, f–h, j–l, n–p). Data are from two independent experiments (a–p) and are presented as mean ± s.e.m. in b–d, f–h, j–l, n–p. See also Supplementary Fig. S1.
