Fig. 1: Cryo-EM structures of human NALCN in complex with FAM155A.
From: Structure of the human sodium leak channel NALCN in complex with FAM155A
a Cryo-EM map of human NALCN in complex with FAM155A. NALCN and FAM155A are colored gray and orange, respectively. The map was contoured at 0.8 threshold level in ChimeraX70. b Local resolution map estimated by cryoSPARC52 and generated in Chimera57. c Overall structure of the NALCN-FAM155A complex presented in two side views. The protein structure is shown in cartoon. NALCN is domain colored with repeats I, II, III, IV, and the CTD in light gray, green, yellow, cyan, and slate, respectively. The III-IV linker and FAM155A are colored orange. Lipid molecules and the sugar moieties at the glycosylation sites are shown as sticks. The color schemes are applied in all figures. All structure figures were prepared with PyMOL71.
