Fig. 7: Native CH1–CH2 domains display different sub-cellular localizations.
From: Biased localization of actin binding proteins by actin filament conformation
a Localization of BPAG1 ABD (magenta) relative to utrnWT (green) in HeLa cells. Scale bar is 5 µm. b Localization of Nesprin II ABD (magenta) relative to utrnWT (green). c Localization of Nesprin II ABD (magenta) relative to utrnWT (green) in PLB cells. Images shown are representative examples taken from a set of at least 10 different images. Scale bar is 5 µm. d Sequence alignment of native CH1–CH2 domains. Residue K121 for utrnWT highlighted in yellow (top) and the N-terminal region prior to CH1–CH2 and its truncation in yellow (bottom). Identical residues are annotated with ‘*’, strongly conserved with ‘:’, and weakly conserved with ‘.’.
