Fig. 8: Syndecan-1 loss disrupts growth and migration programs. | Nature Communications

Fig. 8: Syndecan-1 loss disrupts growth and migration programs.

From: A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia

Fig. 8

a Schematic of RNAseq workflow. b GSEA analysis of WT vs. Sdc1−/− bcCML RNAseq showing impact on oncogenic pathways. c GSEA analysis of WT vs. Sdc1−/− bcCML RNAseq showing impact on drug resistance/relapse pathways. d Heat map of selected genes falling within the GSEA oncogenic and resistance/relapse pathways. e GSEA analysis of WT vs. Sdc1−/− bcCML RNAseq showing impact on adhesion/migration pathways. f Heat map of integrin gene expression in Sdc1−/− bcCML falling within the GSEA adhesion/migration pathways. g Network analysis of genes downregulated in Sdc1−/− bcCML by RNAseq crossed to a recently published bcCML CRISPR screen.

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