Table 1 Affinity of TDP-43 variants and Aβ interaction. The rate constants kon, koff, and KD defined as koff/kon were determined by Octet RED96 system to probe the interaction between TDP-43 and Aβ40.

From: TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease

 

kon (1/Ms)

koff (1/s)

KD(M)

TDP-43_FL

3.4 × 104

<1.0 × 10−7

<1.0 ×  10-12

TDP-43_265

5.7 × 103

5.6 × 10-4

9.9 × 10-8

TDP-43_N-term

N.D.

N.D.

N.D.

TDP-43_RRM1 + 2

9.0 × 103

<1.0 × 10-7

<1.0 × 10-12

  1. N.D.: unable to be determined due to absence of significant binding signal.
Back to article page