Table 4 Gene set enrichment analysis of significant methylation differences associated with AD Braak stage identified in meta-analysis using Wallenius’ noncentral hypergeometric test which adjusted for different number of CpGs associated with each gene.
Gene Set | Description | P-value | FDR |
|---|---|---|---|
GO:0002684 | Positive regulation of immune system process | 4.00E−07 | 2.94E−04 |
GO:0022409 | Positive regulation of cell–cell adhesion | 3.88E−10 | 1.96E−06 |
GO:0030217 | T cell differentiation | 3.32E−06 | 1.99E−03 |
GO:0050863 | Regulation of T cell activation | 1.35E−07 | 1.62E−04 |
GO:0050870 | Positive regulation of T cell activation | 4.89E−07 | 3.27E−04 |
GO:0043312 | Neutrophil degranulation | 5.28E−05 | 1.97E−02 |
GO:0030097 | Hemopoiesis | 1.10E−07 | 1.39E−04 |
GO:0006952 | Defense response | 1.57E−07 | 1.78E−04 |
GO:0098609 | Cell–cell adhesion | 3.23E−07 | 2.72E−04 |
GO:0097530 | Granulocyte migration | 7.42E−05 | 2.68E−02 |
GO:0002523 | Leukocyte migration involved in inflammatory response | 2.54E−06 | 1.56E−03 |
GO:0002573 | Myeloid leukocyte differentiation | 3.76E−06 | 2.05E−03 |
GO:0002429 | Immune response-activating cell surface receptor signaling pathway | 1.55E−05 | 7.21E−03 |
GO:0006909 | Phagocytosis | 5.32E−06 | 2.75E−03 |
GO:0071706 | Tumor necrosis factor superfamily cytokine production | 1.07E−04 | 3.69E−02 |
GO:0098883 | Synapse pruning | 3.42E−05 | 1.41E−02 |
GO:0045123 | Cellular extravasation | 5.37E−05 | 1.97E−02 |
GO:0016477 | Cell migration | 7.73E−05 | 2.75E−02 |
GO:0050854 | Regulation of antigen receptor-mediated signaling pathway | 1.29E−04 | 4.38E−02 |
KEGG:hsa04640 | Hematopoietic cell lineage | 1.55E−04 | 3.96E−02 |
KEGG:hsa04145 | Phagosome | 3.01E−04 | 3.96E−02 |
KEGG:hsa04060 | Cytokine–cytokine receptor interaction | 3.53E−04 | 3.96E−02 |
KEGG:hsa04062 | Chemokine signaling pathway | 5.87E−04 | 4.95E−02 |
