Table 3 FUT2 (rs601338) and ABO (rs505922) main and stratified effects in the COPSAC_severe study (discovery), and the COPSAC birth cohorts (replication).

Discovery (COPSAC_severe)
Gene	Analysis	OR [95% CI]	P value	Cases/controls
FUT2	Main effect	1.17 [1.07–1.29]	0.001	1204/5328
	ABO = TT	0.94 [0.81–0.10]	0.45	410/2199
	ABO = TC	1.29 [1.13–1.48]	2.0 × 10⁻⁴	623/2435
	ABO = CC	1.54 [1.18–2.02]	0.001	171/694
ABO	Main effect	1.16 [1.05–1.27]	0.002	1204/5328
	FUT2 = AA	0.83 [0.65–1.05]	0.12	194/1095
	FUT2 = AG	1.12 [0.98–1.28]	0.10	612/2624
	FUT2 = GG	1.43 [1.21–1.69]	2.2 × 10⁻⁵	398/1609
FUT2 × ABO	Interaction	1.29 [1.12–1.48]	3.2 × 10⁻⁴	1204/5328
Replication (COPSAC birth cohorts)
FUT2	Main effect	1.31 [1.04; 1.67]	0.02	191/727
	ABO = TT	0.99 [0.67; 1.47]	0.96	64/317
	ABO = TC	1.38 [0.99; 1.94]	0.06	103/327
	ABO = CC	2.44 [1.20; 5.30]	0.02	24/83
ABO	Main effect	1.27 [1.00; 1.62]	0.05	191/727
	FUT2 = AA	0.94 [0.49; 1.73]	0.84	27/142
	FUT2 = AG	1.10 [0.78; 1.55]	0.57	93/367
	FUT2 = GG	1.93 [1.26; 3.00]	0.003	71/218
FUT2 × ABO	Interaction	1.50 [1.05; 2.17]	0.03	191/727
FUT2 × ABO	Risk score	2.82 [1.56; 5.10]	5.7 × 10⁻⁴	191/727

The logistic regression models were adjusted for ten principal components and sex for the discovery and for cohort status and sex for the replication. The reported P values are not corrected for multiple comparisons.
P < 0.05 is in bold.

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