Fig. 7: Proposed model for the mechanisms used by GBS during BBB crossing. | Nature Communications

Fig. 7: Proposed model for the mechanisms used by GBS during BBB crossing.

From: An original infection model identifies host lipoprotein import as a route for blood-brain barrier crossing

Fig. 7

GBS (green circle) first has to adhere to the ECM layer, before making its way through. It then crosses the PG layer through a paracellular mechanism and/or cellular damages, likely supported or enhanced by acidosis. The bacteria adhere to the SPG surface via Blr-LpR2 (yellow Y) interaction, allowing its internalisation through endocytosis and leading to its transcellular traversal. In the absence of Blr, GBS uses an alternative, albeit less efficient, mechanism for brain invasion, via SPG damages through an unknown process.

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