Fig. 3: Substrate scope of the alcohol-surrogated Grignard-type reaction.
From: Empowering alcohols as carbonyl surrogates for Grignard-type reactions
Reaction conditions: 1a (0.6 mmol), 2a (0.2 mmol), Ru(PPh3)3Cl2 (5 mol %), ligand (5 mol %) and K3PO4 (2 equiv) in 2-MeTHF at 70 °C under N2 atmosphere for 24 h. See Supplementary Information (SI) for details. Yield of isolated product was reported otherwise noted. a Ru-PNP-1 was used as catalyst. b 1H NMR yield was determined using mesitylene as an internal standard. c The reaction was conducted at 100 °C, with 1a (0.8 mmol) and Ru-PNP-2 being the catalyst.
