Fig. 5: SLC25A51 controls NAD mitochondrial levels.
From: Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
a Schematic view of the TCA and ETC pathway/complexes in the mitochondria. Metabolites depleted in SLC25A51 but not in SLC25A3 KOs are shown in orange boxes. Enzymes with similar essentiality profiles as SLC25A51 across the DepMap dataset are shown in red. b Plot of metabolites differentially abundant in ΔSLC25A51 cells (as average abundance of the two KO clones available) vs. wt cells. Only metabolites with an absolute log2(fold change) above 1 are shown (n = 2 technical replicates). Metabolites directly involved in the TCA cycle are labeled in orange. Source data are provided as a Source Data file. c Fold change in mitochondrial NAD content in HAP1 cells with the indicated genotypes (mean ± SD, n = 2 technical replicates). Source data are provided as a Source Data file.
