Fig. 3: SARS-CoV-2-infected K18 hACE2 transgenic mice show a marked cytokine storm in selected tissues.
From: Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice
a Lungs, b spleen, and c brain. Student’s t test, two-tailed, C57BL/6 vs. K18 hACE2 p < 0.05; p < 0.005; p < 0.0005; two-way ANOVA C57BL/6 or K18 hACE2 transgenic mice over time, p < 0.05; p < 0.005; p < 0.0005, M ± SEM, n = 8 mice (50:50 male:female per time-point studied, except mock n = 2 mice). DPI days post infection. Data are representative over two independent experiments. Source data are provided as a Source Data file.
