Fig. 2: Hydrogels that present cationic interfaces with host cells exhibit increased FBR severity. | Nature Communications

Fig. 2: Hydrogels that present cationic interfaces with host cells exhibit increased FBR severity.

From: Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions

Fig. 2

a, b Survey images of stromal and inflammatory cells (CD13), astrocytes (GFAP), and all cell nuclei (DAPI) at 1 week after injection of nonionic and anionic a, and cationic b hydrogels. c–e Quantification of total immunohistochemical staining. c, d Total CD13 in non-neural c and neural d tissue compartments. not significant (NS), ***P < 0.0001, two-way ANOVA with Bonferroni. e Total GFAP in caudate putamen, NS, one-way ANOVA with Bonferroni. Graphs are mean ± s.e.m with individual data points showing n = 10, 6, 5, 5, 6, 12, 5, 5, 5, 5 mice per group for DCHMO, DCHE, DCHMOE15, HAMC, MC, DCHK, DCHMM, DCHMOK15, DCHMOK10, and CHIT, respectively.

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