Fig. 3: Different hydrogels attract inflammatory responses that differ in intensity and cellular phenotype. | Nature Communications

Fig. 3: Different hydrogels attract inflammatory responses that differ in intensity and cellular phenotype.

From: Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions

Fig. 3

a Detail images of differences in inflammatory cell recruitment 1 week after injection of DCHMO, DCHK, DCHMM hydrogels (G). b Detail images showing that CNS-derived P2RY12-positive microglia do not migrate into non-neural tissue compartments in spite of different FBRs evoked by DCHMO, DCHK, DCHMM. c Detail images of hydrogel-tissue interface showing the escalating recruitment and persistence of Ly6B2-positive neutrophils at cationic hydrogel surfaces at 1 week after injection. d Quantification of total Ly6B2 staining for hydrogels 1 week after injection. Not significant (NS) and **P = 0.0011 for CHIT and DCHK versus DCHMM, respectively, one-way ANOVA with Bonferroni. e Table summarizing the combination of antibodies used to identify different inflammatory cell types. Graphs show mean ± s.e.m with individual data points showing n = 5 mice per group.

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