Fig. 5: pDCs from IFNlow and IFNhigh SLE patients have distinct transcriptomic profiles. | Nature Communications

Fig. 5: pDCs from IFNlow and IFNhigh SLE patients have distinct transcriptomic profiles.

From: Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity

Fig. 5

a Sorted pDCs from HC (n = 7), At-Risk (n = 4), and SLE (n = 13) were classified according to the expression level of the IFN score described. b Average expression level of IFN score measured in samples described in a. c Expression level of representative ISGs in sorted pDCs from sample groups described in a. d Differentially expressed transcripts in IFNlow SLE pDCs (n = 543), IFNhigh SLE pDCs (n = 674), and At-Risk pDCs (n = 114) compared to HC pDCs. e Summary of the Reactome Pathway Enrichment in differentially expressed genes of the pDCs from IFNlow and IFNhigh subgroups compared to HC pDCs.

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