Fig. 8: Stimulated keratinocytes have a high expression of type I IFNs in autoimmunity. | Nature Communications

Fig. 8: Stimulated keratinocytes have a high expression of type I IFNs in autoimmunity.

From: Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity

Fig. 8

a IFNK expression in the epidermis of SLE patient with the inactive disease before UV provocation. b IFNK expression in the epidermis of the same SLE patient after UV provocation. c–e Human keratinocytes were isolated from fresh skin biopsies and were then cultured in the absence or presence of Poly I:C (1 μg/mL) or Poly dA:dT (100 ng/mL). The expression level of IFNK (c), IFNB1 (d), IFNL1 (e) in keratinocytes from healthy controls (HC), At-Risk individuals (At-Risk), SLE patients (SLE), and patients with cutaneous discoid lupus erythematosus (CDLE) after in vitro culture for 24 h. Data are represented as mean ± SEM. Scale bars: 100 µm. *P < 0.05. Two-way ANOVA (c–e).

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