Fig. 3: TGFβ-neutralization affects the tumor ECM architecture. | Nature Communications

Fig. 3: TGFβ-neutralization affects the tumor ECM architecture.

From: TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

Fig. 3

a Cryopreserved 4T1 tumors were sectioned, stained with Dapi and antibodies against ERTR7 and αSMA, and subjected to confocal microscopic analysis. Insets show an enlargement of the boxed area. Images are representative of 6 samples from two independent experiments. b Collagen fibers were visualized with second-harmonic imaging microscopy. c Analysis of the magnitude of the transcriptional changes induced by anti-TGFβ treatment in vivo on cell populations identified in 4T1 by single cell RNAseq, plotted against the overall TGFβ receptor expression of each cell cluster. n = 4 mice per group from 2 independent experiments.

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