Fig. 2: Knockout of CCL7 promotes NSCLC tumorigenesis of the KP mouse model. | Nature Communications

Fig. 2: Knockout of CCL7 promotes NSCLC tumorigenesis of the KP mouse model.

From: CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer

Fig. 2

a A scheme induction of NSCLC in KrasLSL−G12D/+Tp53fl/fl (KP) and KrasLSL−G12D/+Tp53fl/flCcl7−/− (KP7) mice. KP or KP7 mice were anesthetized with sodium pentobarbital followed by intranasal injection of Ad-Cre (1.5 × 106 pfu/mouse). b Survival of KP (n = 31) or KP7 (n = 29) mice after injection of Ad-Cre. c Images of HE-stained lungs of KP and KP7 mice intranasally injected with Ad-Cre for 6, 8 or 10 weeks. d–f Tumor numbers (d), sizes (e), and areas (f) of KP (n = 5, 19 or 16) and KP7 (n = 5, 12 or 16) mice injected with Ad-Cre for 6, 8 or 10 weeks, respectively. Log-rank analysis (b) or two-tailed student’s t-test (d–f). n.s., not significant. Graphs show mean ± SEM (d–f). Scale bars, 5 mm (c). Data are combined results of four independent experiments (b–f). Source data are provided as a source data file.

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