Fig. 4: CNOT3 deletion up-regulates pro-apoptotic genes during positive selection. | Nature Communications

Fig. 4: CNOT3 deletion up-regulates pro-apoptotic genes during positive selection.

From: The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression

Fig. 4

a Scatter plot of genes expressed in Cnot3f/f and Cnot3f/f Cd4-Cre thymocytes during positive selection. Red dots indicate significantly up or down-regulated genes (2-fold change, FDR P < 0.05). b Gene ontology analysis of genes significantly up-regulated in Cnot3f/f or Cnot3f/f Cd4-Cre thymocytes during positive selection. c Heat map (Z-scored expression) of pro-apoptotic genes up-regulated in positive selection.

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