Fig. 3: Domain motions and lattice breathing in DNA origami.
From: Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution
a Overlay of three exemplary 3D classes determined from the Twisttower dataset. b Overlay of exemplary 3D frames of a principal component analysis (PCA) of the heterogeneity in the Pointer-v2 dataset. c Top left: cryo-EM map determined treating the Twisttower as one rigid body. Right: cryo-EM maps of subbodies analyzed using multibody refinement. Bottom left: Frankenstein map. d As in c, but for a 48-helix-brick object, with an arbitrary division into four subbodies.
