Fig. 6: AUC of tumor-normal classifiers on the TCGA test set and CPTAC validation set for LUAD and LUSC cancers.

Classification AUCs of each TCGA-trained tumor/normal classifier applied to LUAD and LUSC images from TCGA (reserved “test” data) and CPTAC (external “validation” data, LUAD: n = 1055, LUSC: n = 1060) are shown. a Bar graphs comparing test and validation AUCs on LUAD and b LUSC slides. c Scatter plot of test AUC versus validation AUC for LUAD and d LUSC. TCGA train and test sample sizes are provided in Fig. 2a.