Fig. 2: Statistically strongest population mode of functional connectivity deviations related to loneliness.
From: The default network of the human brain is associated with perceived social isolation
Loneliness is linked to functional coupling shifts (on z-score scale) with increased intra-network connectivity especially in the default network and decreased inter-network connectivity of the visual cortex with various other neural systems, including the default network. The best partial least-squares mode was computed and found statistically significant at p < 0.05 according to non-parametric permutation testing (false discovery rate, one-sided test, no additional adjustment for multiple comparisons). L/R denotes left/right hemisphere. The shown machine-learning model was fitted once to our whole UKB sample, but brain-loneliness associations held up to cross-validated out-of-sample testing in functional MRI (Supplementary Fig. 11). Source data are provided as a Source Data file.
