Fig. 3: Conservation of the XIST architecture in human and mouse.
From: Structural modularity of the XIST ribonucleoprotein complex
a PARIS analysis of mouse Xist RNA structure in HATX mES cells. The structure model is the duplexes detected by PARIS. The gene structure tracks are the two mouse mature Xist isoforms. Mouse Xist repeats were detected using the Tandem Repeat Finder71,72. b Comparison of human and mouse Xist PARIS-determined structures. The mouse Xist DGs are lifted to human coordinates for comparison with the human XIST PARIS data from 293T cells. The p value was estimated based on 1000 shuffles, where the overlap of all shuffled structures were below experimentally determined ones (exact p value not applicable). c A highly conserved long-range duplex structure as detected by PARIS in human and mouse (likely the “boundary element”). Source data are provided as a Source data file.
