Fig. 8: Model for regulation of muscle fibers size related to scaling relationship.
From: Myonuclear content regulates cell size with similar scaling properties in mice and humans
Our model proposes that the number of myonuclei in a fiber segment is determined by growth signals during development and hypertrophy. The number of nuclei and a setpoint a (which is a productivity number for each nucleus) determine cellular dimensions. The number of nuclei scales invariably sublinearly to cell volume (b < 1), but linearly to cell surface (b = 1).
