Fig. 6: ZK therapeutic effect in mice. | Nature Communications

Fig. 6: ZK therapeutic effect in mice.

From: Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

Fig. 6

a Schematic representation of 1,25D3 and ZK administration to mice. Serum calcium (b) and PTH (c) levels, and duodenal (d) and renal (e) relative Cyp24a1 transcript levels, 24 h after the last administration of vehicle, 1 µg/kg 1,25D3, or 1 µg/kg 1,25D3 and 1 µg/kg ZK. Dashed line in (b) represents the maximal normo-calcemic concentration (10.7 mg/dL). b n = 6 mice/condition. c–e n = 3 mice/condition. Data are represented as mean + s.e.m. *p < 0.05 vs. vehicle, #p < 0.05 vs. 1,25D3, one-way ANOVA with Tukey post-hoc test. The exact significant p-values are provided in Supplementary Table 4.

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