Fig. 3: Overall structure of rNaV1.5C/LqhIII complex and LqhIII binding site. | Nature Communications

Fig. 3: Overall structure of rNaV1.5C/LqhIII complex and LqhIII binding site.

From: Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

Fig. 3

a Cartoon representation of the overall structure of the NaV1.5C/LqhIII. LqhIII, DIV-VS and DIII-DIV linker were colored in purple, blue and orange, respectively. The same color scheme is applied hereafter in this paper unless specified otherwise. The glycosyl moieties are shown in sticks colored in yellow. The black dash square is indicated for panel (b). b Zoom-in view of LqhIII binding to the DIV-VS. The black dash square indicated for panel (d). c The NMR structure of the LqhIII (PDB code: 1FH3) indicating the flexibility of the β2β3 loop and C-terminus. d Detailed interactions between LqhIII and DIV-VS. Key residues shown in sticks were labeled. Interaction surfaces of the DIV-VS (blue) and the LqhIII (purple). Key residues for the interaction shown in yellow shading and embedded sticks.

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