Fig. 4: Conformational Change of DIV-VS. | Nature Communications

Fig. 4: Conformational Change of DIV-VS.

From: Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

Fig. 4

a, b Structures of the activated NaV1.5 DIV-VS and intermediate-activated NaV1.5 DIV-VS were colored in grey and blue, respectively. Gating charges (grey or blue), ENC (red), HCS (yellow), and INC (red) were shown in sticks. The shift of each gating charge was indicated by black dashed lines. c Superposition of NaV1.5 DIV-VS between activated and intermediate-activated state. Red arrows indicate the conformational changes. d Superposition of the intermediate-activated NaV1.5 DIV-VS and resting-state NaVAb-VS.

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