Fig. 1: Protein-altering variants with effect on lipid and liver-related blood traits.
From: Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease
Smile plot comparing the frequency of the blood-trait increasing allele with the allele’s effect size for protein-altering variants significantly (P < 5 × 10−8) associated with a lipid (HDL-C, LDL-C, TG, TC) or liver (ALT, ALP, AST, GGT) trait. The most significant trait is shown for variants with significant association for multiple traits. Color indicates the trait category for which the variant is significant, with loss-of-function variants shown as x. Power curve (dashed line) denotes estimated 90% power in the meta-analysis with a sample size of N = 210,000 at alpha = 5 × 10−8.
