Fig. 4: Phenome-wide association study in UK Biobank (N = 408,961 participants) based on presumed causal protein-altering variants with impact on liver-related blood traits in The HUNT Study (N = 69,479).
From: Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease
The figure displays phenome-wide statistically significant (P < 3.5 × 10−5) associations between selected protein-altering variants (n = 21) with impact on one or more of the 9 liver-related blood traits and selected cardiovascular, liver, and metabolic phenotypes derived from ICD codes in UK Biobank. Arrows denote the direction of effect for the minor allele. Larger arrows signify more significant associations. Statistically insignificant associations are not displayed. Please see Supplementary Fig. 10 and Supplementary Data 15 for the full phenome-scan across all traits and variants available for testing in UKB (n = 24). The ZNF529 LoF variant could not be imputed into the UK Biobank.
