Fig. 10: Activation of SF1 neurons induces energy expenditure. | Nature Communications

Fig. 10: Activation of SF1 neurons induces energy expenditure.

From: An excitatory ventromedial hypothalamus to paraventricular thalamus circuit that suppresses food intake

Fig. 10

a–e As compared to vehicle treatment, DREADD activation of SF1 neurons with J60 via i.p. injections in the VMH SF1 neuron hM3Dq-transduced mice (n = 6) increased O2 consumption (a p = 0.0003), CO2 production (b p = 0.0008), energy expenditure (c p = 0.0003), and heat production (d p = 0.0003), while no apparent effect was observed on locomotion (e). f–j In the VMH SF1 neuron mCherry-transduced mice (n = 8), J60 administration via i.p. injections did not elicit alterations on O2 consumption (f), CO2 production (g), energy expenditure (h), heat production (i), or locomotion (j). Two-way ANOVA with Sidak post hoc tests were performed. Data represent mean ± s.e.m. ***p < 0.001.

Back to article page